Contrast-induced nephropathy (CIN) is traditionally defined as a 25% or a 0.5mg/dL increase in serum creatinine value over the baseline at 48-72 hours after contrast administration. Various prophylactic measures including IV hydration using NS or sodium bicarbonate or administering N-acetylcysteine, amongst others, are often used to try and prevent CIN in at risk patients receiving contrast. But do they really work? Two landmark RCTs published recently in Lancet and NEJM give us some definitive answers. Learn more about them on our first Journal Watch video below!
You can read the Lancet and the NEJM articles discussed in the video by clicking on the links. To understand more on why the results are not completely unexpected, read my open-access commentary on the AMACING trial published in NMJI.
– Akshay Baheti, Tata Memorial Hospital
PS : If the embedded video is not opening, you can view the video on YouTube by clicking here.